DETERMINATION OF URINARY 3,4-DIHYDROXY-MANDELIC ACID (DOMA)

Mandelic Acid in the Treatment of Urinary Infections.

The urinary excretion of mandelic acid administered intravenously to cats.

MANDELIc acid, when administered to animals, may be recovered almost quantitatively from the urine. Moreover, when mandelic acid appears in the body as the result of metabolic processes, it is supposed to be excreted without further change [Knoop, 1905; Dakin, 1922; Quick, 1928]. Neubauer [1909], Neubauer & Fischer [1910], Neubauer & Gross [1910] and Neubauer & Warburg [1910] claimed that after...

Urinary vanillyl-mandelic acid (VMA) excretion by chronically anaemic children.

Hypoxia has been regarded as one of the many factors stimulating augmented catecholamine biosynthesis (Vogt, 1960). Plasma levels of epinephrine and norepinephrine were found to be increased in newborns with the respiratory distress syndrome or placental insufficiency (Cheek, Malinek, and Fraillon, 1963). Infants with severe heart failure eliminate in the urine twice as much metanephrine, norme...

Enzymatic Method for Determination of Vanillyl Mandelic Acid.

An enzymatic method is described for the measurement of vanillyl mandelic acid (VMA). The method utilizes an L-mandelic acid dehydrogenase preparation from Pseudomonas fluorescens A-312 to catalyze the transformation of VMA to vanillin. The method is specific for VMA becauseonly the final product, vanillin, will absorb maximally at 350 m/L. The results compare favorably with the method of Pisan...

Plasma cortisol, urinary 17-hydroxycorticoids, and urinary vanilyl mandelic acid after acute myocardial infarction.

Serial estimations ofplasma cortisol were made on 24 patients with acute myocardial infarction. Raised levels were found in 23 patients. The maximal level was observed within 12 hours of infarction in 78 per cent and between I2 and 24 hours in 22 per cent ofpatients. A positive correlation was found between the maximal cortisol level and the maximal levels of serum aspartate aminotransferase an...